Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during
aging but are functionally impaired. However, the role of HSC-intrinsic and-extrinsic aging …

Aging is the progressive decline or loss of function at the cellular, tissue, and organismal
levels that ultimately leads to death. A number of external and internal factors, including diet …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …

The mammalian hematopoietic system is remarkably efficient in meeting an organism's vital
needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over …

Aging leads to functional decline of the hematopoietic system, manifested by an increased
incidence of hematological disease in the elderly. Deterioration of hematopoietic integrity …

Hematopoiesis is the process by which both fetal and adult organisms derive the full
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …