Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the
hyperglycemic hyperosmolar state Page 1 ISPAD CLINICAL PRACTICE CONSENSUS …

The article presents a chapter of the guidelines on pediatric diabetes in the International
Society for Pediatric and Adolescent Diabetes (ISPAD) Clinical Practice Consensus …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

Insulin has been shown to have antinatriuretic actions in humans and animal models.
Moreover, endogenous hyperinsulinemia and insulin infusion have been correlated to …

Nearly all renal tubular epithelial cells express insulin receptor. The insulin receptor in the
distal tubule appears to modulate BP, but the role of the insulin receptor in the proximal …

Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in
mammals. In the K+-secreting principal cells of the distal nephron, electrogenic Na+ …