H3Africa: current perspectives
N Mulder, A Abimiku, SN Adebamowo… - Pharmacogenomics …, 2018 - Taylor & Francis
Precision medicine is being enabled in high-income countries by the growing availability of
health data, increasing knowledge of the genetic determinants of disease and variation in …
health data, increasing knowledge of the genetic determinants of disease and variation in …
Evaluating the promise of inclusion of African ancestry populations in genomics
AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …
known, and the resultant scientific and ethical limitations are becoming increasingly …
Short-and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa
FB Tamburini, D Maghini, OH Oduaran… - Nature …, 2022 - nature.com
Human gut microbiome research focuses on populations living in high-income countries and
to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of …
to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of …
Regional and sex differences in the prevalence and awareness of hypertension: an H3Africa AWI-Gen study across 6 sites in sub-Saharan Africa
Background There is a high prevalence of hypertension and related cardiovascular
diseases in sub-Saharan Africa, yet few large studies exploring hypertension in Africa are …
diseases in sub-Saharan Africa, yet few large studies exploring hypertension in Africa are …
Low and differential polygenic score generalizability among African populations due largely to genetic diversity
African populations are vastly underrepresented in genetic studies but have the most
genetic variation and face wide-ranging environmental exposures globally. Because …
genetic variation and face wide-ranging environmental exposures globally. Because …
Genetic substructure and complex demographic history of South African Bantu speakers
Abstract South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the
population in South Africa. Despite clear linguistic and geographic diversity, the genetic …
population in South Africa. Despite clear linguistic and geographic diversity, the genetic …
Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across
Africa. This may be a result of an increasingly urbanized lifestyle characterized by the …
Africa. This may be a result of an increasingly urbanized lifestyle characterized by the …
Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry
AB Kamiza, SM Touré, F Zhou, O Soremekun… - Nature …, 2023 - nature.com
Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …
Regional patterns and association between obesity and hypertension in Africa: evidence from the H3Africa CHAIR study
Hypertension and obesity are the most important modifiable risk factors for cardiovascular
diseases, but their association is not well characterized in Africa. We investigated regional …
diseases, but their association is not well characterized in Africa. We investigated regional …
Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits
Genetic associations for lipid traits have identified hundreds of variants with clear differences
across European, Asian and African studies. Based on a sub-Saharan-African GWAS for …
across European, Asian and African studies. Based on a sub-Saharan-African GWAS for …