M Locati, G Curtale, A Mantovani - Annual Review of Pathology …, 2020 - annualreviews.org
Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …
Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic variation associated with …
AI Lim, T McFadden, VM Link, SJ Han, RM Karlsson… - Science, 2021 - science.org
INTRODUCTION One fundamental property of the immune system is its ability to develop memory of previous encounters, resulting in enhanced responsiveness to subsequent …
Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune- related tissue-supporting activities. The roots of this heterogeneity and versatility are only …
Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …
Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid …
EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …