Targeting the epigenetic regulation of antitumour immunity

SJ Hogg, PA Beavis, MA Dawson… - Nature reviews Drug …, 2020 - nature.com
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Diversity, mechanisms, and significance of macrophage plasticity

M Locati, G Curtale, A Mantovani - Annual Review of Pathology …, 2020 - annualreviews.org
Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

A Nott, IR Holtman, NG Coufal, JCM Schlachetzki, M Yu… - Science, 2019 - science.org
Noncoding genetic variation is a major driver of phenotypic diversity, but functional
interpretation is challenging. To better understand common genetic variation associated with …

Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

AI Lim, T McFadden, VM Link, SJ Han, RM Karlsson… - Science, 2021 - science.org
INTRODUCTION One fundamental property of the immune system is its ability to develop
memory of previous encounters, resulting in enhanced responsiveness to subsequent …

[HTML][HTML] Determinants of resident tissue macrophage identity and function

C Blériot, S Chakarov, F Ginhoux - Immunity, 2020 - cell.com
Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis

JS Seidman, TD Troutman, M Sakai, A Gola, NJ Spann… - Immunity, 2020 - cell.com
Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

Activity-regulated transcription: bridging the gap between neural activity and behavior

EL Yap, ME Greenberg - Neuron, 2018 - cell.com
Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

LL Chen, C Morcelle, ZL Cheng, X Chen, Y Xu… - Nature cell …, 2022 - nature.com
As one of the most induced genes in activated macrophages, immune-responsive gene 1
(IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid …

The how and why of lncRNA function: an innate immune perspective

EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade

SS Gu, W Zhang, X Wang, P Jiang, N Traugh, Z Li… - Cancer discovery, 2021 - AACR
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …