Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Macrophages have protective roles in immunity to pathogens, tissue development,
homeostasis and repair following damage. Maladaptive immunity and inflammation provoke …

Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the
phagocytic clearance of cellular debris has been considered an integral component of …

The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …

Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian
carcinoma often metastasizes to the peritoneal cavity. Here, we found 2 peritoneal …

The origin and functional specialization of dermal macrophages in cutaneous infections
have been little studied. In this paper, we show that a strain of Leishmania major (L. major …

Current immunosuppressive therapy has led to excellent short-term survival rates in organ
transplantation. However, long-term graft survival rates are suboptimal, and a vast number of …

Macrophages were first described as phagocytic immune cells responsible for maintaining
tissue homeostasis by the removal of pathogens that disturb normal function. Historically …

During the life of a human being, several tons of apoptotic cells and debris are produced.
These apoptotic particles should be cleared quickly and accurately from the body, as they …