Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

Aberrant expression of epigenetic regulators of gene expression contributes to initiation and
progression of cancer. During recent years, considerable research efforts have focused on …

Background—Epigenetic programming, dynamically regulated by histone acetylation, is a
key mechanism regulating cell proliferation and survival. Little is known about the …

Current therapies for human parasite infections rely on a few drugs, most of which have
severe side effects, and their helpfulness is being seriously compromised by the drug …

It is now clear that histone acetylation plays key roles in regulating gene transcription in both
eukaryotes and prokaryotes, the acetylated form inducing gene expression while …

Introduction: Glioblastoma multiforme is the most common and aggressive primary brain
tumor. Valproate has been used as an anti-epileptic drug and mood stabilizer for decades …

Endometrial stromal sarcomas are rare and molecular mechanisms involved in their
pathogenesis are poorly understood. Covalent modifications of histone proteins, in particular …

Histone deacetylases (HDACs) are important enzymes that effect post-translational
modifications of proteins by altering the acetylation state of lysine residues. HDACs control …

Gemcitabine (GCB), which functions via the inhibition of DNA synthesis, is commonly used
in the treatment of bladder cancer; however, its response rate is not satisfactory due to the …

Objective Maternal embryonic leucine-zipper kinase (MELK) shows oncogenic properties in
basal-like breast cancer, a cancer subtype sharing common molecular features with high …