HIV-1 latency in monocytes/macrophages

A Kumar, W Abbas, G Herbein - Viruses, 2014 - mdpi.com
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the
monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T …

Cellular reservoirs of HIV-1 and their role in viral persistence

A Alexaki, Y Liu, B Wigdahl - Current HIV research, 2008 - ingentaconnect.com
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of
the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can …

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

V Le Douce, G Herbein, O Rohr, C Schwartz - Retrovirology, 2010 - Springer
The introduction of the highly active antiretroviral therapy (HAART) has greatly improved
survival. However, these treatments fail to definitively cure the patients and unveil the …

Epidemiology, pathophysiology, and treatment of Kaposi sarcoma—associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric …

RJ Sullivan, L Pantanowitz, C Casper… - Clinical Infectious …, 2008 - academic.oup.com
Kaposi sarcoma—associated herpesvirus infection is associated with the development of 3
proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric …

The world‐wide incidence of Kaposi's sarcoma in the HIV/AIDS era

Z Liu, Q Fang, J Zuo, V Minhas, C Wood… - HIV medicine, 2018 - Wiley Online Library
Objectives Kaposi's sarcoma (KS) is a multicentric angioproliferative cancer of endothelial
origin typically occurring in the context of immunosuppression or immunodeficiency …

Eradication of HIV-1 from the macrophage reservoir: an uncertain goal?

W Abbas, M Tariq, M Iqbal, A Kumar, G Herbein - Viruses, 2015 - mdpi.com
Human immunodeficiency virus type 1 (HIV-1) establishes latency in resting memory CD4+
T cells and cells of myeloid lineage. In contrast to the T cells, cells of myeloid lineage are …

Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection

J West, B Damania - Journal of virology, 2008 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with several different human
malignancies, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric …

The macrophage: a therapeutic target in HIV-1 infection

A Kumar, G Herbein - Molecular and cellular therapies, 2014 - Springer
Human immunodeficiency virus (HIV) is still a serious global health concern responsible for
more than 25 million deaths in last three decades. More than 34 million people are living …

Molecular biology of KSHV in relation to AIDS-associated oncogenesis

W Greene, K Kuhne, F Ye, J Chen, F Zhou… - Aids-Associated Viral …, 2007 - Springer
In 1872, the famed Hungarian dermatologist Moritz Kaposi characterized an “idiopathic
multiple pigmented sarcoma” which is now known as Kaposi's sarcoma (KS). 424 For most …

Kaposi's sarcoma-associated herpesvirus increases PD-L1 and proinflammatory cytokine expression in human monocytes

KM Host, SR Jacobs, JA West, Z Zhang, LM Costantini… - MBio, 2017 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with the human malignancy
Kaposi's sarcoma and the lymphoproliferative disorders primary effusion lymphoma and …