Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a
complex mixture of thousands of bioactive compounds, and some of them have numerous …

Several studies have reported that the host-microbe interactions in the gut modulate the host
serotonin or 5-hydroxytryptamine (5-HT) system. Here, we evaluated the effects of …

The choroid plexus (ChP) epithelium is a source of secreted signaling factors in
cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop …

Variability characterizes the complexity of biological systems and is essential for their
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …

Depression is a common and severe mental disease that places a heavy burden on human
society, which can lead to decreased cognitive function, energy loss, insomnia, and even …

Gut microbiota (GM) is a major component of the gastrointestinal tract. Growing evidence
suggests that it has various effects on many distal organs including the male reproductive …

Obesity is a complex, multifactorial disease that is a major public health issue worldwide.
Currently approved anti-obesity medications and lifestyle interventions lack the efficacy and …

With the increase in human mean age, the prevalence of neurodegenerative diseases (NDs)
also rises. This negatively affects mental and physiological health. In recent years, evidence …

Highlights•The metabolic responses of zebrafish exposed to PE and PES MPs were
significantly altered.•The enrichment pathway analysis shows disruption of lipid and fatty …