The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …

Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …

BACKGROUND Multiple laboratory tests are used to diagnose and manage patients with
diabetes mellitus. The quality of the scientific evidence supporting the use of these tests …

The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to
shorten lifespan. Impaired insulin action in peripheral tissues is a major pathogenic factor …

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid homeostasis by controlling the expression of a range of enzymes required for …

The CC motif chemokine receptor–2 (CCR2) regulates monocyte and macrophage
recruitment and is necessary for macrophage-dependent inflammatory responses and the …

This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive
gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both …