Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …

Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is
characterized by recursive infections of erythrocytes, leading to clinical symptoms and …

The malaria-causing parasite, Plasmodium falciparum completely remodels its host red
blood cell (RBC) through the export of several hundred parasite proteins, including …

Highlights•Isoprenoid precursors and CoA are essential metabolites generated by
apicoplast-localized enzymes.•Isoprenoids play an essential role in apicoplast …

Despite the recent successes of artemisinin-based antimalarial drugs, many still die from
severe malaria, and eradication efforts are hindered by the limited drugs currently available …

Twenty years since the publication of the Plasmodium falciparum and P. berghei genomes
one-third of their protein-coding genes still lack functional annotation. In the absence of …

Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …

Malaria parasites contain an essential organelle called the apicoplast that houses metabolic
pathways for fatty acid, heme, isoprenoid, and iron–sulfur cluster synthesis. Surprisingly …

In the last 10 years, proximity‐dependent biotinylation (PDB) techniques greatly expanded
the ability to study protein environments in the living cell that range from specific protein …

Plasmodium vivax infects hepatocytes to form schizonts that cause blood infection, or
dormant hypnozoites that can persist for months in the liver before leading to relapsing …