Macrophage polarity and disease control

S Kadomoto, K Izumi, A Mizokami - International Journal of Molecular …, 2021 - mdpi.com
Macrophages are present in most human tissues and have very diverse functions. Activated
macrophages are usually divided into two phenotypes, M1 macrophages and M2 …

Innate immunity in tuberculosis: host defense vs pathogen evasion

CH Liu, H Liu, B Ge - Cellular & molecular immunology, 2017 - nature.com
The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Monocyte subsets: phenotypes and function in tuberculosis infection

P Sampath, K Moideen, UD Ranganathan… - Frontiers in …, 2018 - frontiersin.org
Monocytes are critical defense components that play an important role in the primary innate
immune response. The heterogeneous nature of monocytes and their ability to differentiate …

Macrophage: a cell with many faces and functions in tuberculosis

F Ahmad, A Rani, A Alam, S Zarin, S Pandey… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …

Macrophage heterogeneity and plasticity in tuberculosis

A Khan, VK Singh, RL Hunter… - Journal of leukocyte …, 2019 - academic.oup.com
Macrophages are the primary host cells for Mycobacterium tuberculosis, the causative agent
of tuberculosis (TB), during its intracellular survival in humans. The pathogen has a …

The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection

H Shen, ZW Chen - Cellular & molecular immunology, 2018 - nature.com
Abstract Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-
related cytokines because they are either produced by Th17/Th22 cells or involved in their …

Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases

CM McClean, DM Tobin - FEMS Pathogens and Disease, 2016 - academic.oup.com
Macrophages play a central role in mycobacterial pathogenesis. Recent work has
highlighted the importance of diverse macrophage types and phenotypes that depend on …

Human immunology of tuberculosis

TJ Scriba, AK Coussens, HA Fletcher - Microbiology spectrum, 2017 - Am Soc Microbiol
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …

Tuberculosis exacerbates HIV-1 infection through IL-10/STAT3-dependent tunneling nanotube formation in macrophages

S Souriant, L Balboa, M Dupont, K Pingris… - Cell reports, 2019 - cell.com
The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act
synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis …

Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

MP La Manna, V Orlando, F Dieli, P Di Carlo, A Cascio… - PloS one, 2017 - journals.plos.org
Tuberculosis (TB) is one of the most important cause of morbidity and death among
infectious diseases, and continuous efforts are needed to improve diagnostic tools and …