CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors

E Camors, HH Valdivia - Frontiers in pharmacology, 2014 - frontiersin.org
Ryanodine receptors (RyRs) and inositol triphosphate receptors (InsP3Rs) are structurally
related intracellular calcium release channels that participate in multiple primary or …

The cardiac ryanodine receptor phosphorylation hotspot embraces PKA in a phosphorylation-dependent manner

O Haji-Ghassemi, Z Yuchi, F Van Petegem - Molecular cell, 2019 - cell.com
Ryanodine receptors (RyRs) are intracellular Ca 2+ release channels controlling essential
cellular functions. RyRs are targeted by cyclic AMP (cAMP)-dependent protein kinase A …

Dual ablation of the RyR2‐Ser2808 and RyR2‐Ser2814 sites increases propensity for pro‐arrhythmic spontaneous Ca2+ releases

R Janicek, EM Camors, DM Potenza… - The Journal of …, 2024 - Wiley Online Library
During exercise or stress, the sympathetic system stimulates cardiac contractility via β‐
adrenergic receptor (β‐AR) activation, resulting in phosphorylation of the cardiac ryanodine …

Ablation of three major phospho-sites in RyR2 preserves the global adrenergic response but creates an arrhythmogenic substrate

J Zheng, H Dooge, HH Valdivia, FJ Alvarado - bioRxiv, 2024 - biorxiv.org
Background: Ryanodine receptor 2 (RyR2) is one of the first substrates undergoing
phosphorylation upon catecholaminergic stimulation. Yet, the role of RyR2 phosphorylation …

Mechanisms of Ryanodine Receptor 2 Regulation in Cardiac Pathophysiology

FA Guillén - 2017 - search.proquest.com
Abstract The Ryanodine Receptor type 2 (RyR2) is the major calcium-release channel in the
heart, where it is fundamental for excitation-contraction coupling, the process transducing …

Mechanisms of Ryanodine Receptor 2 Regulation in Cardiac Pathophysiology

F Alvarado Guillen - 2017 - deepblue.lib.umich.edu
The Ryanodine Receptor type 2 (RyR2) the major calcium-release channel in the heart,
where it is fundamental for excitation-contraction coupling, the process transducing electrical …

[引用][C] CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors

N Li