Double strand breaks (DSBs) are the most detrimental type of DNA damage that must be
repaired to ensure genome integrity and cell survival. Unrepaired or improperly repaired …

Over the course of DNA replication, DNA lesions, transcriptional intermediates and protein-
DNA complexes can impair the progression of replication forks, thus resulting in replication …

Alternative lengthening of telomeres (ALT) is a recombination process that maintains
telomeres in the absence of telomerase and helps cancer cells to survive. Yeast has been …

Saccharomyces cerevisiae Pif1 is a multi-functional DNA helicase that plays diverse roles in
the maintenance of the nuclear and mitochondrial genomes. Two isoforms of Pif1 are …

Double strand DNA breaks (DSBs) are dangerous events that can result from various
causes including environmental assaults or the collapse of DNA replication. While the …

Break-induced replication (BIR) proceeds via a migrating D-loop for hundreds of kilobases
and is highly mutagenic. Previous studies identified long single-stranded (ss) nascent DNA …

Nonrandom DNA segregation (NDS) is a mitotic event in which sister chromatids carrying
the oldest DNA strands are inherited exclusively by one of the two daughter cells. Although …

La recombinaison homologue (RH) est une des voies majeures de réparation des
dommages de l'ADN telles que les cassures double brin (CDB). Cette voie est également …

Abstract Break Induced Replication (BIR) is one of the homologous recombination pathways
to repair DNA double strand breaks. BIR plays important roles in maintaining genomic …

Heterozygous mutations in BRCA1 or BRCA2 predispose carriers to an increased risk for
breast or ovarian cancer. Both BRCA1 and BRCA2 (BRCA1/2) play an integral role in …