The lack of effective treatments for most neurological diseases has prompted the search for
novel therapeutic options. Interestingly, neuroinflammation is emerging as a common …

Cerebral ischemia (stroke) induces injury to the cerebral endothelium that may contribute to
parenchymal injury and worsen outcome. This review focuses on current preclinical studies …

Most neurological diseases, including stroke, lead to some degree of blood–brain barrier
(BBB) dysfunction. A significant portion of BBB injury is caused by inflammation, due to pro …

Aims: Neuroinflammation and oxidative stress are deemed the prime causes of brain injury
after cerebral ischemia/reperfusion (I/R). Since the silent mating-type information regulation …

Intracarotid arterial hyperosmolar mannitol (ICAHM) blood–brain barrier disruption (BBBD)
is effective and safe for delivery of therapeutics for central nervous system malignancies …

Sepsis-associated encephalopathy (SAE) is an acutely progressing brain dysfunction
induced by systemic inflammation. The mechanism of initiation of neuroinflammation during …

Endothelial dysfunction is a key proponent of pathophysiological process of traumatic brain
injury (TBI). We previously demonstrated that extracellular vesicles (EVs) released from …

At present, Stroke is still one of the leading causes of population death worldwide and leads
to disability. Traditional Chinese medicine plays an important role in the prevention or …

Background Clinical and animal studies have shown that transcutaneous auricular vagus
nerve stimulation (ta-VNS) exerts neuroprotection following cerebral ischemia. Studies have …

Hypertension is the most prevalent and modifiable risk factor for stroke, vascular cognitive
impairment, and Alzheimer's disease. However, the mechanistic link between hypertension …