[HTML][HTML] Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis
M Chang, W Chen, R Xia, Y Peng, P Niu, H Fan - Molecules, 2023 - mdpi.com
Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that
accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is …
accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is …
[HTML][HTML] Therapeutic strategies to overcome fibrotic barriers to nanomedicine in the pancreatic tumor microenvironment
Simple Summary Pancreatic cancer is difficult to treat. Novel treatment strategies are
urgently needed to improve the survival rate, which is approximately 10% five years after …
urgently needed to improve the survival rate, which is approximately 10% five years after …
Discoidin domain receptor 1 (DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis
X Li, Q Li, B Xiong, H Chen, X Wang, D Zhang - Pharmacological Research, 2022 - Elsevier
Background and aims Discoidin domain receptor 1 (DDR1) encodes a receptor tyrosine
kinase involved in multiple physiological and pathological processes. DDR1 is expressed in …
kinase involved in multiple physiological and pathological processes. DDR1 is expressed in …
[HTML][HTML] Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds
Y Wu, C Zhang, M Guo, W Hu, Y Qiu, M Li… - Frontiers in …, 2022 - frontiersin.org
Chronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal
adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is …
adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is …
[HTML][HTML] Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis
F Kong, Y Pan, D Wu - Biomedicines, 2024 - mdpi.com
In the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs)
emerge as central figures. These cells, initially in a dormant state characterized by the …
emerge as central figures. These cells, initially in a dormant state characterized by the …
[HTML][HTML] Genetic and pharmacological tools to study the role of discoidin domain receptors in kidney disease
CM Borza, G Bolas, A Pozzi - Frontiers in Pharmacology, 2022 - frontiersin.org
Following injury the kidney undergoes a repair process, which results in replacement of the
injured tissue with little evidence of damage. However, repetitive injuries or inability of the …
injured tissue with little evidence of damage. However, repetitive injuries or inability of the …
Discoidin domain receptor 1 may be involved in biological barrier homeostasis
X Li, H Chen, D Zhang - Journal of Clinical Pharmacy and …, 2022 - Wiley Online Library
What is known and objective Discoidin domain receptor 1 (DDR1) is a receptor tyrosine
kinase involved in the pathological processes of several diseases, such as keloid formation …
kinase involved in the pathological processes of several diseases, such as keloid formation …
[HTML][HTML] Discoidin Domain Receptor 1 as a potent therapeutic target in solid tumors
S Bibi, W Zeng, P Zheng, SMM Mehmandousti, T Jin - hLife, 2024 - Elsevier
Despite significant discoveries in basic cancer research and improvements in treatment
options and clinical outcomes, cancer remains a major public health concern worldwide …
options and clinical outcomes, cancer remains a major public health concern worldwide …