Overexposure of the developing fetus to glucocorticoids is hypothesised to be one of the key
mechanisms linking early life development with later life disease. The maternal …

BackgroundCortisol plays a multifaceted role in major depression disorder (MDD). Diurnal
rhythms are disturbed, there is increased resistance to the feedback action of …

Objective: To formulate clinical practice guidelines for hormonal replacement in
hypopituitarism in adults. Participants: The participants include an Endocrine Society …

Objective: The objective of the study was to develop clinical practice guidelines for the
diagnosis of Cushing's syndrome. Participants: The Task Force included a chair, selected by …

Objective: The objective of the study was to develop clinical practice guidelines for the
diagnosis of Cushing's syndrome. Participants: The Task Force included a chair, selected by …

The hypothalamic-pituitary-adrenal (HPA) axis is a classic neuroendocrine system. One of
the best ways to understand the HPA axis is to appreciate its dynamics in the variety of …

Context: Adrenal failure secondary to hypothalamo-pituitary disease is a common clinical
problem which has serious repercussions. It is essential to perform validated diagnostic …

Routine assessment of the hypothalamic–pituitary–adrenal axis relies on the measurement
of total serum cortisol levels. However, most cortisol in serum is bound to corticosteroid …

Neuroendocrinology of bone is a new area of research based on the evidence that pituitary
hormones may directly modulate bone remodeling and metabolism. Skeletal fragility …

Sex differences in the response to stress contribute to sex differences in somatic,
neurological, and psychiatric diseases. Despite a growing literature on the mechanisms that …