The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Transient receptor potential (TRP) proteins form a superfamily Ca2+-permeable cation
channels regulated by a range of chemical and physical stimuli. Structural analysis of a …

Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological
and pathophysiological processes, making it a promising drug target. Here we present cryo …

Transient receptor potential V2 (TRPV2) has been proposed to be a high-threshold
thermosensor. However, further elucidation of the channel properties and physiological role …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Macrophage phagocytosis is critical for defense against pathogens. Whereas many steps of
phagocytosis involve ionic flux, the underlying ion channels remain ill defined. Here we …

Transient receptor potential (TRP) ion channels are emerging as a new set of membrane
proteins involved in a vast array of cellular processes and regulated by a large number of …

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …

Probenecid was initially developed with the goal of reducing the renal excretion of
antibiotics, specifically penicillin. It is still used for its uricosuric properties in the treatment in …