Nucleic acid recognition during prokaryotic immunity

CF Baca, LA Marraffini - Molecular Cell, 2025 - cell.com
Parasitic elements often spread to hosts through the delivery of their nucleic acids to the
recipient. This is particularly true for the primary parasites of bacteria, bacteriophages …

Systematic functional assessment of antiphage systems in their native host

E David, C Plantady, S Poissonnier, J Le Boulch… - bioRxiv, 2024 - biorxiv.org
Bacterial resistance to bacteriophages (phages) relies on two primary strategies: preventing
phage attachment and blocking post-attachment steps. These latter mechanisms are …

Phage defence system abundances vary across environments and increase with viral density

S Meaden, E Westra, PC Fineran - bioRxiv, 2025 - biorxiv.org
The defence systems bacteria use to protect themselves from their viruses are
mechanistically and genetically diverse. Yet the ecological conditions that predict when …

Innate antiviral systems are major defensome components that drive prophage distribution in Acinetobacter baumannii

A Moreno-Rodríguez, A Rubio, A Garzón, Y Smani… - bioRxiv, 2024 - biorxiv.org
Phages are guilty of killing daily almost half of bacterial cells, while bacteria have developed
defense mechanisms that number in the dozens. Individual defense systems are gained and …