The Na+, K+-ATPase is a ubiquitous membrane transport protein in mammalian cells,
responsible for establishing and maintaining high K+ and low Na+ in the cytoplasm required …

Astrocytes are the main cell type responsible for the regulation of brain homeostasis,
including the maintenance of ion gradients and neurotransmitter clearance. These …

It is generally accepted that electrochemical gradients of monovalent ions across the plasma
membrane, created by the coupled function of pumps, carriers and channels, are involved in …

Targeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging
therapy. Cardiac glycosides were recently proved to be a broad-spectrum senolytics. Here …

Apoptosis of vascular smooth muscle cells (VSMCs) plays an important role in remodeling of
vessel walls, one of the major determinants of long-term blood pressure elevation and an …

AMP-activated protein kinase (AMPK) is a cellular energy gauge and a major regulator of
cellular energy homeostasis. Once activated, AMPK stimulates nutrient uptake and the ATP …

We have previously described that chronic administration of ouabain induces hypertension
and functional alterations in mesenteric resistance arteries. The aim of this study was to …

Na+, K+-ATPase is the only known receptor of cardiotonic steroids (CTS) whose interaction
with catalytic α-subunits leads to inhibition of this enzyme. As predicted, CTS affect …

Our review focuses on the recent data showing that gene transcription and translation are
under the control of signaling pathways triggered by modulation of the intracellular …

Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is
known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na …