Centromeres are the chromosomal domains required to ensure faithful transmission of the
genome during cell division. They have a central role in preventing aneuploidy, by …

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin
structures that can respond to changes in the transcriptional requirements of the cell …

Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …

The faithful transmission of genetic information to daughter cells is central to maintaining
genomic stability and relies on the accurate and complete duplication of genetic material …

Abstract Mammalian Bre1 complexes (BRE1A/B (RNF20/40) in humans and Bre1a/b
(Rnf20/40) in mice) function similarly to their yeast homolog Bre1 as ubiquitin ligases in …

Rif1, originally recognized for its role at telomeres in budding yeast, has been implicated in a
wide variety of cellular processes in mammals, including pluripotency of stem cells …

The notion that telomeres are essential for chromosome linearity stems from the existence of
two chief dangers: inappropriate DNA damage response (DDR) reactions that mistake …

In human cells homologous recombination (HR) is critical for repair of DNA double strand
breaks (DSBs) and rescue of stalled or collapsed replication forks. HR is facilitated by …

DNA double strand breaks (DSBs) are highly toxic to the cells and accumulation of DSBs
results in several detrimental effects in various cellular processes which can lead to …

Schizosaccharomyces pombe Rad3 checkpoint kinase and its human ortholog ATR are
essential for maintaining genome integrity in cells treated with genotoxins that damage DNA …