N Tomar, RK De - Immunoinformatics, 2014 - Springer
A large volume of data relevant to immunology research has accumulated due to sequencing of genomes of the human and other model organisms. At the same time, huge …
The accurate prediction of the binding affinities of ligands to proteins is a major goal in drug discovery and personalized medicine. The time taken to make such predictions is of similar …
W Schreiner, R Karch, B Knapp… - … mathematical methods in …, 2012 - Wiley Online Library
Molecular dynamics simulations have to be sufficiently long to draw reliable conclusions. However, no method exists to prove that a simulation has converged. We suggest the …
PV Coveney, PW Fowler - Journal of the Royal Society …, 2005 - royalsocietypublishing.org
We discuss the modern approaches of complexity and self-organization to understanding dynamical systems and how these concepts can inform current interest in systems biology …
V Zoete, MB Irving, O Michielin - Journal of Molecular …, 2010 - Wiley Online Library
Recognition by the T‐cell receptor (TCR) of immunogenic peptides (p) presented by class I major histocompatibility complexes (MHC) is the key event in the immune response against …
Background MHC class II proteins bind oligopeptide fragments derived from proteolysis of pathogen antigens, presenting them at the cell surface for recognition by CD4+ T cells …
Xenorhabdus nematophila secretes insecticidal proteins to kill its larval prey. We have isolated an∼ 58-kDa GroEL homolog, secreted in the culture medium through outer …
C Ruckert, MT Fiorillo, B Loll, R Moretti… - Journal of Biological …, 2006 - ASBMB
An interesting property of certain peptides presented by major histocompatibility complex (MHC) molecules is their acquisition of a dual binding mode within the peptide binding …
D Barh, K Blum, MA Madigan - 2016 - books.google.com
A reflection of the explosion of research and development in this field, this book explores applications of omics in bioinformatics, cancer research and therapy, diabetes research …