[HTML][HTML] TGF-β in hepatic stellate cell activation and liver fibrogenesis—updated 2019
Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
[HTML][HTML] May the force be with you (or not): The immune system under microgravity
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
Biomimetic tumor microenvironments based on collagen matrices
The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …
providing structural and mechanical support to cells and tissues, and regulating multiple cell …
[HTML][HTML] Collagen fibril density modulates macrophage activation and cellular functions during tissue repair
J Sapudom, WKE Mohamed, A Garcia-Sabaté… - Bioengineering, 2020 - mdpi.com
Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …
[HTML][HTML] Piezo1 channel as a potential target for hindering cardiac fibrotic remodeling
Fibrotic tissues share many common features with neoplasms where there is an increased
stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries …
stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries …
[HTML][HTML] Matrix remodeling and hyaluronan production by myofibroblasts and cancer-associated fibroblasts in 3D collagen matrices
The tumor microenvironment is a key modulator in cancer progression and has become a
novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and …
novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and …
[HTML][HTML] Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: Mechanical strain amplitude dependency of …
The spatiotemporal interaction and constant iterative feedback between fibroblasts,
extracellular matrix, and environmental cues are central for investigating the fibroblast …
extracellular matrix, and environmental cues are central for investigating the fibroblast …
[HTML][HTML] Fibroblast differentiation and matrix remodeling impaired under simulated microgravity in 3D cell culture model
Exposure to microgravity affects astronauts' health in adverse ways. However, less is known
about the extent to which fibroblast differentiation during the wound healing process is …
about the extent to which fibroblast differentiation during the wound healing process is …
Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling
Obesity increases the risk and worsens the prognosis for breast cancer due, in part, to
altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase …
altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase …
3D scaffold‐based macrophage fibroblast coculture model reveals IL‐10 dependence of wound resolution phase
F Ullm, P Riedl, A Machado de Amorim… - Advanced …, 2020 - Wiley Online Library
Persistent inflammation and impaired repair in dermal wound healing are frequently
associated with cell–cell and cell–matrix miscommunication. A direct coculture model of …
associated with cell–cell and cell–matrix miscommunication. A direct coculture model of …