Engineering the microbiome for animal health and conservation

S Jin Song, DC Woodhams, C Martino… - Experimental …, 2019 - journals.sagepub.com
Interest in animal microbiomes as therapeutics is rapidly expanding, as techniques to study
the microbial world decrease in cost and increase in accessibility and case studies from …

Disease-induced assemblage of a plant-beneficial bacterial consortium

RL Berendsen, G Vismans, K Yu, Y Song… - The ISME …, 2018 - academic.oup.com
Disease suppressive soils typically develop after a disease outbreak due to the subsequent
assembly of protective microbiota in the rhizosphere. The role of the plant immune system in …

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL‐1β

C Schwartz, T Moran, SP Saunders, A Kaszlikowska… - Allergy, 2019 - Wiley Online Library
Background Atopic dermatitis (AD) is one of the most common skin diseases with a
multifactorial etiology. Mutations leading to loss of skin barrier function are associated with …

Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis

CA Santee, NA Nagalingam, AA Faruqi, GP DeMuri… - Microbiome, 2016 - Springer
Background Upper respiratory infections (URI) and their complications are a major
healthcare burden for pediatric populations. Although the microbiology of the nasopharynx …

Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease

J O'Sullivan, S Patel, GE Leventhal, RS Fitzgerald… - Gut …, 2025 - Taylor & Francis
Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel
disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility …

A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) difficile Infection in Mice, whereas a High-Carbohydrate Diet Protects

CC Mefferd, SS Bhute, JR Phan, JV Villarama, DM Do… - Msystems, 2020 - Am Soc Microbiol
Clostridioides difficile (formerly Clostridium difficile) infection (CDI) can result from the
disruption of the resident gut microbiota. Western diets and popular weight-loss diets drive …

Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study

W Sangster, JP Hegarty, KM Schieffer… - Frontiers in …, 2016 - frontiersin.org
This study sought to characterize the bacterial and fungal microbiota changes associated
with Clostridium difficile infection (CDI) among inpatients with diarrhea, in order to further …

IL-17 receptor A maintains and protects the skin barrier to prevent allergic skin inflammation

A Floudas, SP Saunders, T Moran… - The Journal of …, 2017 - journals.aai.org
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of
children and 3% of adults worldwide and is associated with dysregulation of the skin barrier …

Investigational new treatments for Clostridium difficile infection

ME Ivarsson, JC Leroux, B Castagner - Drug discovery today, 2015 - Elsevier
Highlights•Two drugs have been FDA-approved for Clostridium difficile infection in the past
30 years.•Thirteen treatments are currently in clinical development.•The treatments in …

Quantifying bacterial spore germination by single-cell impedance cytometry for assessment of host microbiota susceptibility to Clostridioides difficile infection

JH Moore, A Salahi, C Honrado, C Warburton… - Biosensors and …, 2020 - Elsevier
The germination of ingested spores is often a necessary first step required for enabling
bacterial outgrowth and host colonization, as in the case of Clostridioides difficile (C. difficile) …