Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …

In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …

Novel therapeutic regimens for tissue renewal incorporate mesenchymal stem cells (MSCs)
as they differentiate into a variety of cell types and are a stem cell type that is easy to harvest …

Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released
into the airway and airspace where they bind high-affinity cognate receptors and may …

Severe COVID-19 is characterized by acute respiratory distress syndrome (ARDS)-like
hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ …

The pulmonary epithelial and vascular endothelial cell layers provide two sequential
physical and immunological barriers that together form a semi‐permeable interface and …

Lysophosphatidic acid (LPA), a simple bioactive phospholipid, is present in biological fluids
such as plasma and bronchoalveolar lavage (BAL). It appears to have both pro-and anti …