Systems biology of cancer metastasis

Y Suhail, MP Cain, K Vanaja, PA Kurywchak… - Cell systems, 2019 - cell.com
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

Mechanisms of disseminated cancer cell dormancy: an awakening field

MS Sosa, P Bragado, JA Aguirre-Ghiso - Nature Reviews Cancer, 2014 - nature.com
Metastases arise from residual disseminated tumour cells (DTCs). This can happen years
after primary tumour treatment because residual tumour cells can enter dormancy and …

Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis

Y Touil, W Igoudjil, M Corvaisier, AF Dessein… - Clinical cancer …, 2014 - AACR
Purpose: Metastasis and drug resistance are the major limitations in the survival and
management of patients with cancer. This study aimed to identify the mechanisms …

Tumor cell dormancy

RR Gomis, S Gawrzak - Molecular oncology, 2017 - Wiley Online Library
Metastasis is the primary cause of death in cancer patients and current treatments fail to
provide durable responses. Efforts to treat metastatic disease are hindered by the fact that …

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

P Altea‐Manzano, AM Cuadros, LA Broadfield… - EMBO …, 2020 - embopress.org
Nutrients are indispensable resources that provide the macromolecular building blocks and
energy requirements for sustaining cell growth and survival. Cancer cells require several …

Metastatic tumors to the jaws and mouth

A Hirshberg, R Berger, I Allon, I Kaplan - Head and neck pathology, 2014 - Springer
Metastatic dissemination to the oral cavity is rare and is usually the evidence of a wide
spread disease with an average survival rate of 7 months. In almost a quarter of the cases …

Insights into the role of senescence in tumor dormancy: mechanisms and applications

VJ DeLuca, T Saleh - Cancer and Metastasis Reviews, 2023 - Springer
One of the most formidable challenges in oncology and tumor biology research is to provide
an accurate understanding of tumor dormancy mechanisms. Dormancy refers to the ability of …

Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion

K Warita, T Warita, CH Beckwitt, ME Schurdak… - Scientific reports, 2014 - nature.com
The cholesterol reducing drugs, statins, exhibit anti-tumor effects against cancer stem cells
and various cancer cell lines, exert potent additivity or synergy with existing …

[图书][B] Dr. Susan Love's breast book

SM Love - 2015 - books.google.com
" The Bible for women with breast cancer"--New York Times For more than two decades,
readers faced with a diagnosis of breast cancer have relied on Dr. Susan Love's Breast …

Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling

CH Beckwitt, K Shiraha, A Wells - PloS one, 2018 - journals.plos.org
The HMG-CoA reductase inhibitors, statins, have been used as lipid lowering drugs for
decades and several epidemiological studies suggest statin usage correlates with a …