Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Pericentric heterochromatin silencing at mammalian centromeres is essential for mitotic
fidelity and genomic stability. Defective pericentric silencing has been observed in …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Centromeric chromatin undergoes major changes in composition and architecture during
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …

Safeguarding cell function and identity following a genotoxic stress challenge entails a tight
coordination of DNA damage signaling and repair with chromatin maintenance. How this …

Replication-dependent histones are expressed in a cell cycle regulated manner and supply
the histones necessary to support DNA replication. In mammals, the replication-dependent …

ATRX alterations occur at high frequency in neuroblastoma of adolescents and young
adults. Particularly intriguing are the large N-terminal deletions of ATRX (Alpha …

Within the cell nucleus, the organization of the eukaryotic DNA into chromatin uses histones
as components of its building block, the nucleosome. This chromatin organization …

Background Breast cancer is a heterogeneous disease with different molecular subtypes
that have varying responses to therapy. An ongoing challenge in breast cancer research is …