[HTML][HTML] Coping with stress: how bacteria fine-tune protein synthesis and protein transport
Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
The dynamic SecYEG translocon
J Oswald, R Njenga, A Natriashvili… - Frontiers in Molecular …, 2021 - frontiersin.org
The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …
bacterial adaptation to different environmental conditions. By adjusting the protein …
(p) ppGpp: magic modulators of bacterial physiology and metabolism
W Steinchen, V Zegarra, G Bange - Frontiers in Microbiology, 2020 - frontiersin.org
When bacteria experience growth-limiting environmental conditions, the synthesis of the
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
Novel (p)ppGpp Binding and Metabolizing Proteins of Escherichia coli
Y Zhang, E Zborníková, D Rejman, K Gerdes - MBio, 2018 - Am Soc Microbiol
The alarmone (p) ppGpp plays pivotal roles in basic bacterial stress responses by
increasing tolerance of various nutritional limitations and chemical insults, including …
increasing tolerance of various nutritional limitations and chemical insults, including …
A widespread toxin− antitoxin system exploiting growth control via alarmone signaling
Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the
alarmone (p) ppGpp, a nucleotide second messenger.(p) ppGpp rewires bacterial …
alarmone (p) ppGpp, a nucleotide second messenger.(p) ppGpp rewires bacterial …
Metabolic reprogramming and longevity in quiescence
J Dworkin, CS Harwood - Annual Review of Microbiology, 2022 - annualreviews.org
Since Jacques Monod's foundational work in the 1940s, investigators studying bacterial
physiology have largely (but not exclusively) focused on the exponential phase of bacterial …
physiology have largely (but not exclusively) focused on the exponential phase of bacterial …
CMPK2 restricts Zika virus replication by inhibiting viral translation
Flaviviruses continue to emerge as global health threats. There are currently no Food and
Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore …
Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore …
[HTML][HTML] RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
Summary RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through
synthesis and degradation of the nucleotide alarmone (p) ppGpp. We recently discovered …
synthesis and degradation of the nucleotide alarmone (p) ppGpp. We recently discovered …
Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p) ppGpp
L Czech, CN Mais, H Kratzat, P Sarmah… - Nature …, 2022 - nature.com
The stringent response enables bacteria to respond to nutrient limitation and other stress
conditions through production of the nucleotide-based second messengers ppGpp and …
conditions through production of the nucleotide-based second messengers ppGpp and …
Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest
Several ATPases in the ATP-binding cassette F (ABCF) family confer resistance to
macrolides, lincosamides and streptogramins (MLS) antibiotics. MLS are structurally distinct …
macrolides, lincosamides and streptogramins (MLS) antibiotics. MLS are structurally distinct …