Not so spontaneous: Multi-dimensional representations of behaviors and context in sensory areas

L Avitan, C Stringer - Neuron, 2022 - cell.com
Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely …

Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

Neuronal wiring diagram of an adult brain

S Dorkenwald, A Matsliah, AR Sterling, P Schlegel… - Nature, 2024 - nature.com
Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

The complete connectome of a learning and memory centre in an insect brain

K Eichler, F Li, A Litwin-Kumar, Y Park, I Andrade… - Nature, 2017 - nature.com
Associating stimuli with positive or negative reinforcement is essential for survival, but a
complete wiring diagram of a higher-order circuit supporting associative memory has not …

The neuronal architecture of the mushroom body provides a logic for associative learning

Y Aso, D Hattori, Y Yu, RM Johnston, NA Iyer, TTB Ngo… - elife, 2014 - elifesciences.org
We identified the neurons comprising the Drosophila mushroom body (MB), an associative
center in invertebrate brains, and provide a comprehensive map describing their potential …

A connectome of a learning and memory center in the adult Drosophila brain

S Takemura, Y Aso, T Hige, A Wong, Z Lu, CS Xu… - Elife, 2017 - elifesciences.org
Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

Y Aso, D Sitaraman, T Ichinose, KR Kaun, K Vogt… - elife, 2014 - elifesciences.org
Animals discriminate stimuli, learn their predictive value and use this knowledge to modify
their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes …

Optimal degrees of synaptic connectivity

A Litwin-Kumar, KD Harris, R Axel, H Sompolinsky… - Neuron, 2017 - cell.com
Synaptic connectivity varies widely across neuronal types. Cerebellar granule cells receive
five orders of magnitude fewer inputs than the Purkinje cells they innervate, and cerebellum …

Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila

T Hige, Y Aso, MN Modi, GM Rubin, GC Turner - Neuron, 2015 - cell.com
Although associative learning has been localized to specific brain areas in many animals,
identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the …

The glia of the adult Drosophila nervous system

MC Kremer, C Jung, S Batelli, GM Rubin, U Gaul - Glia, 2017 - Wiley Online Library
Glia play crucial roles in the development and homeostasis of the nervous system. While the
GLIA in the Drosophila embryo have been well characterized, their study in the adult …