Developments in strategies for Quorum Sensing virulence factor inhibition to combat bacterial drug resistance
Quorum sensing (QS) is a complex bacterial intercellular communication system. It is
mediated by molecules called auto-inducers (AIs) and allows coordinated responses to a …
mediated by molecules called auto-inducers (AIs) and allows coordinated responses to a …
Biguanides: Species with versatile therapeutic applications
D Kathuria, AD Raul, P Wanjari, PV Bharatam - European Journal of …, 2021 - Elsevier
Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …
conjugated system. Biguanides are highly basic and hence they are available as salts …
Molecular insights into the interaction of RONS and Thieno [3, 2-c] pyran analogs with SIRT6/COX-2: A molecular dynamics study
SIRT6 and COX-2 are oncogenes target that promote the expression of proinflammatory and
pro-survival proteins through a signaling pathway, which leads to increased survival and …
pro-survival proteins through a signaling pathway, which leads to increased survival and …
[HTML][HTML] Growing emergence of drug-resistant Pseudomonas aeruginosa and attenuation of its virulence using quorum sensing inhibitors: A critical review
A perilous increase in the number of bacterial infections has led to developing throngs of
antibiotics for increasing the quality and expectancy of life. Pseudomonas aeruginosa is …
antibiotics for increasing the quality and expectancy of life. Pseudomonas aeruginosa is …
“What's in a structure?” The story of biguanides
D Kathuria, AA Bankar, PV Bharatam - Journal of Molecular Structure, 2018 - Elsevier
Biguanides are a very interesting class of molecules which have been extensively studied
for their medicinal applications. The structural and electronic structural aspects of …
for their medicinal applications. The structural and electronic structural aspects of …
Quorum sensing inhibitory potential and in silico molecular docking of flavonoids and novel terpenoids from Senegalia nigrescens
Ethnopharmacological relevance Senegalia nigrescens is used in traditional medicine for
the treatment of dysentery and convulsions. Aims of the study This study was aimed at …
the treatment of dysentery and convulsions. Aims of the study This study was aimed at …
Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides
The increasing incidence of multidrug-resistant Gram-negative bacterial pathogens has
focused research on the suppression of bacterial virulence via quorum sensing inhibition …
focused research on the suppression of bacterial virulence via quorum sensing inhibition …
Synthetic accesses to biguanide compounds
Biguanide is a unique chemical function, which has attracted much attention a century ago
and is showing resurgent interest in recent years after a long period of dormancy. This class …
and is showing resurgent interest in recent years after a long period of dormancy. This class …
Synthesis, molecular docking and QSAR studies of 2, 4-disubstituted thiazoles as antimicrobial agents
In present study a series of 2, 4-disubstituted thiazole derivatives was synthesized and
evaluated for their in vitro antibacterial and antifungal activities against B. subtilis, E. coli, S …
evaluated for their in vitro antibacterial and antifungal activities against B. subtilis, E. coli, S …
[HTML][HTML] In silico identification of albendazole as a quorum sensing inhibitor and its in vitro verification using CviR and LasB receptors based assay systems
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Introduction: Quorum sensing inhibition (QSI) is one of the vital tools to overcome emerging …
Introduction: Quorum sensing inhibition (QSI) is one of the vital tools to overcome emerging …