Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …
J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …
research to improve diagnostics, and to discover and test novel preventive and curative …
Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
K Andrysiak, J Stępniewski, J Dulak - Pflügers Archiv-European Journal of …, 2021 - Springer
Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …
Strategies for improving the maturity of human induced pluripotent stem cell-derived cardiomyocytes
Tu et al Strategies to Promote Cardiac Maturation 513 in previous iPSC-CM models.
Together, these results indicate an advanced level of maturity, both structurally and …
Together, these results indicate an advanced level of maturity, both structurally and …
Design and fabrication of an integrated heart-on-a-chip platform for construction of cardiac tissue from human iPSC-derived cardiomyocytes and in situ evaluation of …
F Zhang, KY Qu, B Zhou, Y Luo, Z Zhu, DJ Pan… - Biosensors and …, 2021 - Elsevier
In vitro model of the human cardiac tissues generated from human induced pluripotent stem
cells (hiPSCs) could facilitate drug discovery and patient-specific studies of physiology and …
cells (hiPSCs) could facilitate drug discovery and patient-specific studies of physiology and …
Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges
Recent innovations in differentiating cardiomyocytes from human induced pluripotent stem
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …
Proliferation and maturation: janus and the art of cardiac tissue engineering
During cardiac development and morphogenesis, cardiac progenitor cells differentiate into
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …
Severe cardiac dysfunction and death caused by arrhythmogenic right ventricular cardiomyopathy type 5 are improved by inhibition of glycogen synthase kinase-3β
L Padrón-Barthe, M Villalba-Orero… - Circulation, 2019 - Am Heart Assoc
Background: Arrhythmogenic cardiomyopathy/arrhythmogenic right ventricular
cardiomyopathy (ARVC) is an inherited cardiac disease characterized by fibrofatty …
cardiomyopathy (ARVC) is an inherited cardiac disease characterized by fibrofatty …
Step-by-step fabrication of heart-on-chip systems as models for cardiac disease modeling and drug screening
Cardiovascular diseases are caused by hereditary factors, environmental conditions, and
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …
A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient
After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk …
SD Burnett, AD Blanchette, WA Chiu… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes is one of
the most widely used cell-based models that resulted from the discovery of how non …
the most widely used cell-based models that resulted from the discovery of how non …