[HTML][HTML] Using CRISPR to enhance T cell effector function for therapeutic applications

JJ Freen-van Heeren - Cytokine: X, 2021 - Elsevier
T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in
the fight against cancer. To exert their effector function, T cells produce effector molecules …

Flow-FISH as a tool for studying bacteria, fungi and viruses

JJ Freen-van Heeren - BioTech, 2021 - mdpi.com
Many techniques are currently in use to study microbes. These can be aimed at detecting,
identifying, and characterizing bacterial, fungal, and viral species. One technique that is …

Toll‐like receptor‐2/7‐mediated T cell activation: An innate potential to augment CD8+ T cell cytokine production

JJ Freen‐van Heeren - Scandinavian journal of immunology, 2021 - Wiley Online Library
CD8+ T cells are critical to combat pathogens and eradicate malignantly transformed cells.
To exert their effector function and kill target cells, T cells produce copious amounts of …

Post‐transcriptional control of T‐cell cytokine production: Implications for cancer therapy

JJ Freen‐van Heeren - Immunology, 2021 - Wiley Online Library
As part of the adaptive immune system, T cells are vital for the eradication of infected and
malignantly transformed cells. To perform their protective function, T cells produce effector …

[HTML][HTML] FISHing for COVID‐19: Studying SARS‐CoV‐2 with single‐molecule FISH and flow‐FISH

JJ Freen‐van Heeren - Cytometry, 2022 - ncbi.nlm.nih.gov
For more than 2 years, the COVID-19 pandemic has plagued the world. The causative
agent, SARS-CoV-2, is a single-stranded RNA virus that is easily transmitted, resulting in> …

Posttranscriptional Events Orchestrate Immune Homeostasis of CD8+ T Cells

JJ Freen-van Heeren - Immune Homeostasis: Methods and Protocols, 2024 - Springer
Maintaining immune homeostasis is instrumental for host health. Immune cells, such as T
cells, are instrumental for the eradication of pathogenic bacteria, fungi and viruses …

Assessing Antigen-Specific T Cell Responses Through IFN-γ Enzyme-Linked Immune Absorbent Spot (ELISpot)

JJ Freen-van Heeren, V Palomares Cabeza… - … : Methods and Protocols, 2024 - Springer
T cells are instrumental in protecting the host against invading pathogens and the
development of cancer. To do so, they produce effector molecules such as granzymes …

Journal roundup

JJ Freen-van Heeren - Eur. J. Immunol, 2021 - search.ebscohost.com
B Harnessing high-throughput flow cytometric protein and RNA detection to enhance TIL
therapy b As part of the adaptive immune system, T cells are vital for the protection against …

Transcriptomic profile of ataxia telangiectasia cells treated for 30 days with a low dose of dexamethasone

A Ricci, F Biancucci, M Magnani, M Menotta - All Life, 2021 - Taylor & Francis
Dexamethasone administered by autologous red blood cells (RBCs) is used in clinical trials
and as compassionate therapy to alleviate ataxia telangiectasia (AT) symptoms, providing …

[引用][C] Addressing HIV‐1 latency with flow‐FISH: finding, characterizing and targeting HIV‐1 infected cells

JJ Freen‐van Heeren - Cytometry Part A, 2021 - Wiley Online Library
Since the identification of human immunodeficiency virus 1 (HIV-1) as the pathogen
responsible for acquired immunodeficiency syndrome (AIDS) in the early 1980s, treatment …