Mechanical interactions are fundamental to biology. Mechanical forces of chemical origin
determine motility and adhesion on the cellular scale, and govern transport and affinity on …

The relevance of protein stability for biological function and molecular evolution is widely
recognized. Protein stability, however, comes in two flavours: thermodynamic stability, which …

With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse
function are subjected to substantial stretch. Stretch is a potent stimulus for growth …

I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Folding may be described conceptually in terms of trajectories over a landscape of free
energies corresponding to different molecular configurations. In practice, energy landscapes …

Single-molecule methods have matured into powerful and popular tools to probe the
complex behaviour of biological molecules, due to their unique abilities to probe molecular …

Chemical reactivity underlies our fundamental understanding of many physical and
biological phenomena. Chemical reactions are typically initiated by heat, electric current or …

Recent advances in single molecule experiments have raised many challenges. These
challenges can be met by a proper understanding of the inter-and intra-molecular …

Proteins subjected to an electric field and forced to pass through a nanopore induce
blockades of ionic current that depend on the protein and nanopore characteristics and …

With the recent revolution in Molecular Biology and the deciphering of the Human Genome,
understanding of the building blocks that comprise living systems has advanced rapidly. We …