Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
Recent advances in non-small cell lung cancer targeted therapy; an update review
Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …
mTOR-mediated regulation of immune responses in cancer and tumor microenvironment
The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer
T Pungsrinont, J Kallenbach, A Baniahmad - International journal of …, 2021 - mdpi.com
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging
BK Kennedy, DW Lamming - Cell metabolism, 2016 - cell.com
Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …
mTOR: a pharmacologic target for autophagy regulation
mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR
regulates cell growth and proliferation in response to a wide range of cues, and its signaling …
regulates cell growth and proliferation in response to a wide range of cues, and its signaling …
Making new contacts: the mTOR network in metabolism and signalling crosstalk
M Shimobayashi, MN Hall - Nature reviews Molecular cell biology, 2014 - nature.com
More than 20 years after its discovery, our understanding of target of rapamycin (TOR)
signalling continues to grow. Recent global'omics' studies have revealed physiological roles …
signalling continues to grow. Recent global'omics' studies have revealed physiological roles …
[HTML][HTML] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and
amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with …
amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with …
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
The large serine/threonine protein kinase mTOR regulates cellular and organismal
homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and …
homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and …
mTOR complex 2 signaling and functions
WJ Oh, E Jacinto - Cell cycle, 2011 - Taylor & Francis
The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …