Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

The transition from acute to chronic pain appears to occur in discrete pathophysiological and
histopathological steps. Stimuli initiating a nociceptive response vary, but receptors and …

The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1)
inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo …

Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and
clinical research was directed at the study of stereoselective neuronal actions of opioids …

Pain is a major clinical problem of osteoarthritis (OA). Recently, OA has been thought to be a
disease of the whole joint with both destruction of cartilage and inflammatory components …

The discovery of the cannabinoid receptors CB1 and CB2 in 19881, 2 and 1990, 3
respectively, and of the endogenous cannabinoid ligands (endocannabinoids) …

Cyclooxygenase-2 (COX-2) is an enzyme that plays a key role in inflammatory processes.
Classically, this enzyme is upregulated in inflammatory situations and is responsible for the …

Pain Assessment and Pharmacologic Management, by highly renowned authors Chris
Pasero and Margo McCaffery, is destined to become the definitive resource in pain …