Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …

T‐cell exhaustion is characterized by the stepwise and progressive loss of T‐cell functions
and can culminate in the physical deletion of the responding cells. Exhaustion is well …

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of
infected persons; approximately 50% of these do not respond to therapy. We performed a …

Clearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections …

Resolution of infections depends on the host's ability to mount a protective immune
response. However, an exacerbated response to infections may result in deleterious lesions …

Chronic liver diseases are very common worldwide, particularly those linked to viral hepatitis
and to alcoholic and non-alcoholic fatty liver. Their natural history is variable and long-term …

The hepatic complications of chronic hepatitis C (CHC) usually occur only after progression
to cirrhosis has taken place. Progression to cirrhosis, however, is extremely variable and …

Viral infections can have one of two outcomes: control of viral replication and acute infection
or viral persistence and chronic infection. It is clear that both pathogen and host …

AIM: To study the relationship between the polymorphisms in some cytokines and the
outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. METHODS …