The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Certain members of the gut microbiota exhibit diurnal variations in relative abundance and
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …

Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …

It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …

Abbreviations: ALT, alanine aminotransferase; BMI, body mass index; BODIPY‐C 12, 4, 4‐
difluoro‐5, 7‐dimethyl‐4‐bora‐3a, 4a‐diaza‐s‐Indacene‐3‐dodecanoic acid; ChIP …

PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as
well as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) …

Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …

Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …