Growing evidence shows that there is a comorbid mechanism between the central nervous
system (CNS) and the peripheral organs. The bilateral transmission of signal molecules in …

Extracellular vesicles are important vectors for cell-cell communication and show potential
value for diagnosis and treatment of kidney diseases. The pathologic diagnosis of kidney …

Urinary extracellular vesicles (uEVs) are emerging as non‐invasive biomarkers for various
kidney diseases, but it is unknown how differences in nephron mass impact uEV excretion …

Background The calcium-sensing receptor (CaSR) in the distal convoluted tubule (DCT)
activates the NaCl cotransporter (NCC). Glucose acts as a positive allosteric modulator of …

Research about the effect of exosomes derived from tumor associated macrophages (TAM-
exos) in the distant organ metastasis of breast cancer is limited. In this study, we found that …

Introduction The putative “renal-K switch” mechanism links dietary potassium intake with
sodium retention and involves activation of the sodium chloride (NaCl) cotransporter (NCC) …

The thiazide-sensitive sodium chloride cotransporter (NCC), expressed in the renal distal
convoluted tubule, plays a major role in Na+, Cl-and K+ homeostasis and blood pressure as …

Extracellular vesicles (EVs) are nanoparticles that transmit molecules from releasing cells to
target cells. Recent studies link urinary EVs (uEV) to diverse processes such as infection …

Background: In autosomal dominant polycystic kidney disease (ADPKD) there is an unmet
need for early markers of rapid disease progression to facilitate counseling and selection for …

“Urine can provide us day by day, month by month, and year by year with a serial story of the
major events within the kidney.” Dr. Thomas Addis, pioneer in renal physiology, came to this …