Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

Host immune response against Mycobacterium tuberculosis is mediated by cellular
immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the …

Bovine tuberculosis (bTB) is a chronic granulomatous caseous-necrotising inflammatory
process that mainly affects the lungs and their draining lymph nodes (Ln.). The pathological …

The development of the granuloma and its subsequent degeneration and necrosis, is the
hallmark of infection caused by Mycobacterium tuberculosis. These structures probably …

Non‐human primates, primarily macaques, have been used to study tuberculosis for
decades. However, in the last 15 years, this model has been refined substantially to allow …

Tuberculosis (TB) is a global pandaemic, partially due to the failure of vaccination
approaches. Novel anti-TB vaccines are therefore urgently required. Here we show that …

Non‐human primates (NHPs) are used to model human disease owing to their remarkably
similar genomes, physiology, and immune systems. Recently, there has been an increased …

In the past 2 decades, it has become increasingly clear that nonhuman primates, specifically
macaques, are useful models for human tuberculosis (TB). Several macaque species have …

Nonhuman primates have emerged as an excellent model of human tuberculosis, in large
part because they recapitulate the full spectrum of infection outcome and pathology seen in …

The establishment of an aerosol challenge model in nonhuman primates (NHPs) for the
testing of vaccines against Mycobacterium tuberculosis would assist the global effort to …