In spite of substantial progress made toward understanding cancer pathogenesis, this
disease remains one of the leading causes of mortality. Thus, there is an urgent need to …

Cancer-targeted therapy is an expanding and successful approach in treatment of many
types of cancers. One of the main categories of targeted therapy is use of small molecule …

Abstract In the current study, 5-(pyridin-2-yl)-1, 3, 4-thiadiazol-2-amine (1) was synthesized
via one step reaction of picolinic acid with thiosemicarbazide in the presence of POCl 3 …

Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development,
invasion and metastasis of tumors as well as angiogenesis. In our current research, we …

Bacterial resistance associated to different antibiotics is a limitation for the treatment of
infections and this has stimulated the development of new antimicrobial agents. In this …

In the present study a series of novel 2-(substituted phenyl)-3-(5-phenyl-1, 3, 4-thiadiazol-2-
yl)-2, 3-dihydroquinazolin-4 (1H)-one derivatives were synthesized by refluxing isatoic …

Due to their extensive variety of biological actions, 1, 3, 4-thiadiazole has been the subject of
several investigations. Their antibacterial, anti-inflammatory, anti-cancer, anti-diabetic and …

Amaç: Kanser, tüm dünyada her altı ölümün birinden sorumlu olup, kardiyovasküler
hastalıklardan sonra ikinci en yaygın ölüm sebebidir. Çoklu direnç gelişimi ile birlikte …

Methods: In this basic-applied study, the desired derivatives were synthesized in multiple
steps using convenient methods. Then, the structure of compounds was validated using …

Introduction: Acexazolamide is a new derivative of 1, 3, 4-thiadiazole and acexamic acid.
Materials and methods: In animal experiments, acute toxicity, pharmacological activity and …