Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that
utilize oxidative phosphorylation as the main metabolic pathway to produce energy. Copper …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Ferroptosis is a newly characterized form of programmed cell death, which is driven by the
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …

Scope Naturally occurring quercetin has been found to induce mitophagy and prevent
nonalcoholic fatty liver disease (NAFLD). However, it still remains elusive whether frataxin …

Alcoholic liver disease (ALD) is one of the severe liver diseases, resulting in high morbidity
and mortality. However, frataxin, a mitochondrial protein mainly participating in iron …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …

Iron (Fe) is an essential element that plays a fundamental role in a wide range of cellular
functions, including cellular proliferation, DNA synthesis, as well as DNA damage and …

Iron is an essential nutrient for all living organisms and plays a vital role in many
fundamental biochemical processes, such as oxygen transport, energy metabolism, and …

The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in
many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In …