Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

DA Montero, RM Vidal, J Velasco, S George… - Frontiers in …, 2023 - frontiersin.org
Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease
affecting millions worldwide each year. Cholera is a major public health problem, primarily in …

Advances in phage display based nano immunosensors for cholera toxin

Y Li, K Yang, D Kong, J Ye - Frontiers in Immunology, 2023 - frontiersin.org
Cholera, a persistent global public health concern, continues to cause outbreaks in
approximately 30 countries and territories this year. The imperative to safeguard water …

B-Cell Epitope Mapping of the Vibrio cholera Toxins A, B, and P and an ELISA Assay

SG De-Simone, P Napoleão-Pêgo… - International Journal of …, 2022 - mdpi.com
Oral immunization with the choleric toxin (CT) elicits a high level of protection against its
enterotoxin activities and can control cholera in endemic settings. However, the complete B …

Evaluation of humoral and cellular immune responses against Vibrio cholerae using oral immunization by multi-epitope-phage-based vaccine

E Ghafouri, M Fadaie, Z Amirkhani… - International …, 2024 - Elsevier
Introduction Cholera is a severe gastrointestinal disease that manifests with rapid onset of
diarrhea, vomiting, and high mortality rates. Due to its widespread occurrence in …

Protective effects of anti-CfaB-EtpA-LTB IgY antibody against adherence and toxicity of enterotoxigenic Escherichia coli (ETEC)

F Mohammadkhani, SL Mousavi Gargari… - Journal of Applied …, 2023 - academic.oup.com
Abstract Aim Production of IgY antibodies against CfaB-EtpA-LTB (CEL) chimeric protein
and evaluation of its protective effects against enterotoxigenic Escherichia coli (ETEC) by in …

Challenges and Opportunities in the Process Development of Chimeric Vaccines

S Chauhan, YP Khasa - Vaccines, 2023 - mdpi.com
Vaccines are integral to human life to protect them from life-threatening diseases. However,
conventional vaccines often suffer limitations like inefficiency, safety concerns, unavailability …

Case report: Detection of non-O1/non-O139 Vibrio cholerae in a patient with hepatic space-occupying lesions using metagenomic next-generation sequencing

W Zhang, L Xiao, X Shan, B Dai, C Tang, J Xian… - Frontiers in …, 2024 - frontiersin.org
Introduction/background Vibrio cholerae is the causative agent of the human intestinal
infectious disease cholera, which includes a variety of serogroups. However, there have …

[HTML][HTML] Inactivated Vibrio cholerae strains that express TcpA via the toxT-139F allele induce antibody responses against TcpA

EJ Kim, J Bae, YJ Ju, DB Ju, D Lee, S Son… - … of Microbiology and …, 2022 - ncbi.nlm.nih.gov
Cholera remains a major global public health problem, for which oral cholera vaccines
(OCVs) being a valuable strategy. Patients, who have recovered from cholera, develop …

[HTML][HTML] Intracellular Expression of CTB in Vibrio cholerae Strains in Laboratory Culture Conditions

H Choi, S Son, D Lee, J Bae, E Seo… - … of Microbiology and …, 2023 - ncbi.nlm.nih.gov
The introduction of the toxT-139F allele triggers the expression of TCP (toxin co-regulated
pilus) and CT (cholera toxin) under simple laboratory culture conditions in most Vibrio …

[PDF][PDF] Dynamics of IgM and IgA Antibody Response Profile against Vibrio cholerae Toxins A, B, and P

SG De-Simone, P Napoleão-Pêgo, GC Lechuga… - 2024 - preprints.org
The first immune response controls many bacterial and viral inflammatory diseases. Oral
immunization with cholera toxin (CT) elicits antibodies and can prevent cholerae in endemic …