Analytical characteristics of high-sensitivity cardiac troponin assays

FS Apple, PO Collinson… - Clinical …, 2012 - academic.oup.com
Abstract BACKGROUND Cardiac troponins I (cTnI) and T (cTnT) have received international
endorsement as the standard biomarkers for detection of myocardial injury, for risk …

Troponin elevation in coronary vs. non-coronary disease

S Agewall, E Giannitsis, T Jernberg… - European heart …, 2011 - academic.oup.com
Acute myocardial infarction is defined as myocardial cell death due to prolonged myocardial
ischaemia. Cardiac troponins (cTn) are the most sensitive and specific biochemical markers …

Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations

D Doudesis, KK Lee, J Boeddinghaus, A Bularga… - Nature Medicine, 2023 - nature.com
Although guidelines recommend fixed cardiac troponin thresholds for the diagnosis of
myocardial infarction, troponin concentrations are influenced by age, sex, comorbidities and …

How to use high-sensitivity cardiac troponins in acute cardiac care

K Thygesen, J Mair, E Giannitsis, C Mueller… - European heart …, 2012 - academic.oup.com
Recommendations for the use of cardiac troponin (cTn) measurement in acute cardiac care
have recently been published. 1 Subsequently, a high-sensitivity (hs) cTn T assay was …

Prospective validation of the 0/1-h algorithm for early diagnosis of myocardial infarction

R Twerenbold, JT Neumann, NA Sörensen… - Journal of the American …, 2018 - jacc.org
Background: The safety of the European Society of Cardiology (ESC) 0/1-h algorithm for
rapid rule-out and rule-in of non–ST-segment elevation myocardial infarction (NSTEMI) …

One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T

T Reichlin, C Schindler, B Drexler… - Archives of internal …, 2012 - jamanetwork.com
Background High-sensitivity cardiac troponin (hs-cTn) assays seem to improve the early
diagnosis of acute myocardial infarction (AMI), but it is unknown how to best use them in …

Recommendations for the use of cardiac troponin measurement in acute cardiac care

K Thygesen, J Mair, H Katus, M Plebani… - European heart …, 2010 - academic.oup.com
The release of cardiomyocyte components, ie biomarkers, into the bloodstream in higher
than usual quantities indicates an ongoing pathological process. Thus, detection of elevated …

Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults

CR DeFilippi, JA de Lemos, RH Christenson… - Jama, 2010 - jamanetwork.com
Context Older adults comprise the majority of new-onset heart failure (HF) diagnoses, but
traditional risk-factor prediction models have limited accuracy in this population to identify …

Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction

T Reichlin, A Irfan, R Twerenbold, M Reiter… - Circulation, 2011 - Am Heart Assoc
Background—Current guidelines for the diagnosis of acute myocardial infarction (AMI),
among other criteria, also require a rise and/or fall in cardiac troponin (cTn) levels. It is …

Optimal cutoff levels of more sensitive cardiac troponin assays for the early diagnosis of myocardial infarction in patients with renal dysfunction

R Twerenbold, K Wildi, C Jaeger, MR Gimenez… - Circulation, 2015 - Am Heart Assoc
Background—It is unknown whether more sensitive cardiac troponin (cTn) assays maintain
their clinical utility in patients with renal dysfunction. Moreover, their optimal cutoff levels in …