Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Brains are highly metabolically active organs, consuming 20% of a person's energy at
resting state. A decline in glucose metabolism is a common feature across a number of …

Neuronal necroptosis–an emerging form of regulated cell death associated with
neuroinflammatory signaling: Alzheimer's disease (AD) is characterized by the presence of …

Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic
aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects
millions of individuals globally. AD is associated with cognitive decline and memory loss that …

The interaction between metabolic dysfunction and inflammation is central to the
development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

A recent study showed that while autophagy is usually tied to protein and organelle turnover,
it can also play dual roles in neurodegenerative diseases. Traditionally, autophagy was …