Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Membrane contact sites enable interorganelle communication by positioning organelles in
close proximity using molecular" tethers." With a growing understanding of the importance of …

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …

Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell,
allowing the segregation of sometimes incompatible biochemical reactions into specific …

Store-operated Ca 2+ channels activated by the depletion of Ca 2+ from the endoplasmic
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …

Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …