Filaggrin Mutations Associated with Skin and Allergic Diseases | New England Journal of
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Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in
prevalence around the world. Intensive research is ongoing to understand the mechanisms …

The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the
cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong …

Atopic dermatitis (AD) is a common skin condition, characterized by a complex,
heterogeneous pathogenesis, including skin barrier dysfunctions, allergy/immunology, and …

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies,
cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin …

Allergic contact dermatitis (ACD) is one of the most common skin diseases, consisting of
sensitization and elicitation phases. With the advancement of technology and the discovery …

The skin is essential for survival and protects our body against biological attacks, physical
stress, chemical injury, water loss, ultraviolet radiation and immunological impairment. The …

BACKGROUND: Loss-of-function mutations in filaggrin are major predisposing factors for
atopic dermatitis. Although various reports suggest a critical role for filaggrin in stratum …

Atopic dermatitis (AD) is a chronic skin disorder characterized by pruritus and recurrent
eczematous lesions that are accompanied by T‐helper (Th) 2‐dominated inflammation. AD …