Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …

Bone homeostasis depends on the resorption of bones by osteoclasts and formation of
bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

T cell receptor (TCR) stimulation results in the influx of Ca2+, which is buffered by
mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP …

Cadmium is a common environmental pollutant that accumulates in the bone and kidneys
and causes severe health and social problems. However, the effects of Cd on the …

With the progress of the aging population, bone-related diseases such as osteoporosis and
osteoarthritis have become urgent problems. Recent studies have demonstrated the …

The pannexin proteins represent a new gap junction family. However, the cellular functions
of pannexins remain largely unknown. Here, we demonstrate that pannexin 3 (Panx3) …

The purinergic signalling system, which uses purines and pyrimidines as chemical
transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development …

The adult skeleton is a metabolically active organ system that undergoes continuous
remodeling to remove old and/or stressed bone (resorption) and replace it with new bone …

P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular
influx of Na+ and Ca 2+ and efflux of K+. P2X7 is expressed by a wide variety of cells and its …