The chloroplast epitranscriptome: factors, sites, regulation, and detection methods

N Manavski, A Vicente, W Chi, J Meurer - Genes, 2021 - mdpi.com
Modifications in nucleic acids are present in all three domains of life. More than 170 distinct
chemical modifications have been reported in cellular RNAs to date. Collectively termed as …

Phylogenomics Identifies a New Major Subgroup of Apicomplexans, Marosporida class nov., with Extreme Apicoplast Genome Reduction

V Mathur, WK Kwong, F Husnik… - Genome Biology and …, 2021 - academic.oup.com
The phylum Apicomplexa consists largely of obligate animal parasites that include the
causative agents of human diseases such as malaria. Apicomplexans have also emerged …

Direct nanopore sequencing of mRNA reveals landscape of transcript isoforms in apicomplexan parasites

VV Lee, LM Judd, AR Jex, KE Holt, CJ Tonkin… - …, 2021 - Am Soc Microbiol
Alternative splicing is a widespread phenomenon in metazoans by which single genes are
able to produce multiple isoforms of the gene product. However, this has been poorly …

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

AM Blackwell, Y Jami-Alahmadi, AS Nasamu, S Kudo… - Elife, 2024 - elifesciences.org
Malaria parasites have evolved unusual metabolic adaptations that specialize them for
growth within heme-rich human erythrocytes. During blood-stage infection, Plasmodium …

Apicoplast‐Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites

CO Mamudu, ME Tebamifor, MO Sule… - Advances in …, 2024 - Wiley Online Library
The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that
houses housekeeping processes and metabolic pathways critical to Plasmodium parasites' …

Coordination of apicoplast transcription in a malaria parasite by internal and host cues

Y Kobayashi, K Komatsuya… - Proceedings of the …, 2023 - National Acad Sciences
The malaria parasite Plasmodium falciparum has a nonphotosynthetic plastid called the
apicoplast, which contains its own genome. Regulatory mechanisms for apicoplast gene …

[HTML][HTML] Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development

LM Low, DI Stanisic, MF Good - Microbes and infection, 2018 - Elsevier
The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug
target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here …

Molecular docking, MD simulation, and MMGBSA-binding free energy estimation study identify antibiotic analogs as potential antimalarials targeting housekeeping …

B Naik, D Prusty - Molecular Simulation, 2024 - Taylor & Francis
Plasmodium falciparum exclusively harbours a non-photosynthetic plastid-like organelle
called 'apicoplast,'crucial for survival. The apicoplast genome resembles chloroplasts, albeit …

Chloroplast mRNAs are 3′ polyuridylylated in the Green Alga Pithophora roettleri (Cladophorales)

MJ Meade, GCR Proulex, KM Manoylov… - Journal of …, 2020 - Wiley Online Library
Species within the green algal order Cladophorales have an unconventional plastome
structure where individual coding regions or small numbers of genes occur as linear single …

Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling

P Rai, D Sharma, R Soni, N Khatoon, B Sharma… - Journal of …, 2017 - Springer
Malaria has been present since ancient time and remains a major global health problem in
developing countries. Plasmodium falciparum belongs to the phylum Apicomplexan, largely …