Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …

Neuronal hyperactivity is a key feature of early stages of Alzheimer's disease (AD). Genetic
studies in AD support that microglia act as potential cellular drivers of disease risk, but the …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Identifying cell populations associated with risk variants is essential for uncovering cell-
specific mechanisms that drive disease development and progression. Integrating genome …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow
progression of cognitive impairment and neuronal loss. Currently, approved treatments for …

Summary Microglia (MG), the brain-resident macrophages, play major roles in health and
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …

Microglial reactivity to injury and disease is emerging as a heterogeneous, dynamic, and
crucial determinant in neurological disorders. However, the plasticity and fate of disease …

Neuroinflammation may play an important role in the development of Alzheimer's disease
(AD). Previous studies have reported that lipopolysaccharide (LPS)‐induced …