The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Id proteins are important parts of signaling pathways involved in development, cell cycle and
tumorigenesis. They were first shown to act as dominant negative antagonists of the basic …

The ubiquitously expressed family of ID helix-loop-helix (HLH) proteins function as dominant
negative regulators of basic HLH (bHLH) transcriptional regulators that drive cell lineage …

Transcription factors with bHLH motifs modulate critical events in the development of the
mammalian neocortex. Multipotent cortical progenitors are maintained in a proliferative state …

The cyclins are a family of proteins that are centrally involved in cell cycle regulation and
which are structurally identified by conserved “cyclin box” regions. They are regulatory …

Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in
regulating a variety of cellular processes, including cellular growth, senescence …