Squamous dysplasia—the precursor lesion for esophageal squamous cell carcinoma

PR Taylor, CC Abnet, SM Dawsey - Cancer epidemiology, biomarkers & …, 2013 - AACR
Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers
worldwide, and esophageal squamous dysplasia (ESD) is the only histopathology that …

[HTML][HTML] Cervical esophageal cancer: a gap in cancer knowledge

A Hoeben, J Polak, L Van De Voorde, F Hoebers… - Annals of …, 2016 - Elsevier
Background The aim of this systematic review is to provide an overview of the diagnosis,
treatment options and treatment-related complications of cervical esophageal carcinoma …

A lesson for the maestro of the replication fork: targeting the protein‐binding interface of proliferating cell nuclear antigen for anticancer therapy

VK Bhardwaj, R Purohit - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
The proliferating cell nuclear antigen (PCNA) has emerged as a promising candidate for the
development of novel cancer therapeutics. PCNA is a nononcogenic mediator of DNA …

The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim

T Kan, F Sato, T Ito, N Matsumura, S David, Y Cheng… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Barrett's esophagus (BE) is a highly premalignant disease that
predisposes to the development of esophageal adenocarcinoma (EAC); however, the …

Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation

R Luthra, TT Wu, MG Luthra, J Izzo… - Journal of clinical …, 2006 - ascopubs.org
Purpose Patients with localized esophageal carcinoma have a 5-year survival rate of less
than 20%. Patients are often treated similarly (ie, with preoperative chemoradiotherapy) but …

A multi‐omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma

X Jin, L Liu, J Wu, X Jin, G Yu, L Jia… - Clinical and …, 2021 - Wiley Online Library
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of
esophageal cancer with inferior prognosis. Here, we conducted comprehensive …

The molecular biology of esophageal adenocarcinoma

LB Koppert, BPL Wijnhoven… - Journal of surgical …, 2005 - Wiley Online Library
Background Barrett's esophagus is an acquired metaplastic change that occurs in the distal
esophagus secondary to chronic gastroesophageal reflux. This premalignant condition …

Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis

S Wang, M Zhan, J Yin, JM Abraham, Y Mori, F Sato… - Oncogene, 2006 - nature.com
To investigate the relationship between Barrett's esophagus (BE) and esophageal
adenocarcinoma (EAC), we determined gene expression profiles of discrete pathological …

miR-21-5p promotes cell proliferation by targeting BCL11B in Thp-1 cells

L Zhang, L Yu, Y Liu, S Wang, Z Hou… - Oncology …, 2021 - spandidos-publications.com
Acute myeloid leukemia (AML) is a highly heterogeneous disease that remains untreatable.
MicroRNAs (miRNAs or miRs) play important roles in the pathogenesis of leukemia. miR‑21 …

Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma

H Zhang, L Xu, D Xiao, J Xie, H Zeng, W Cai… - Journal of clinical …, 2006 - jcp.bmj.com
Background: Fascin, an actin-binding protein, is usually expressed at a low level in normal
epithelium, but is markedly up regulated in several types of carcinomas. Reports on fascin …